Roshchupkin D I, Murina M A
Biofizika. 1993 Nov-Dec;38(6):1053-68.
The current knowledge about the mechanisms of the lipid photoperoxidation (LPPO) and the role of the process in the effects of the UV-irradiation of cells and tissues is reviewed. The LPPO in biomembranes occurs as a result of the lipid hydroperoxide phototransformation to free radicals and the antioxidant photolysis. The LPPO significantly depends on the structural state of biomembranes. The UV-radiation stimulates the two types of dark lipid peroxidation (LPO): the free radical non-enzymatic peroxidation, and the cyclooxygenase peroxidation. The UV-radiation produces increase of the membrane ion permeability, decrease (or enhancement) of the aggregatory interaction of cells, and changes of the membrane enzymatic activity. The LPPO and the dark non-enzymatic LPO play an important role in the changes of the membrane functions under the UV-irradiation. The dark non-enzymatic LPO is important for the development of UV erythema. The cyclooxygenase LPO may be responsible for the curative properties of the UV-irradiated blood.
本文综述了目前关于脂质光过氧化作用（LPPO）机制以及该过程在细胞和组织紫外线辐射效应中作用的相关知识。生物膜中的LPPO是脂质氢过氧化物光转化为自由基以及抗氧化剂光解的结果。LPPO显著依赖于生物膜的结构状态。紫外线辐射刺激两种类型的暗脂质过氧化作用（LPO）：自由基非酶促过氧化作用和环氧化酶过氧化作用。紫外线辐射会导致膜离子通透性增加、细胞聚集相互作用减弱（或增强）以及膜酶活性改变。LPPO和暗非酶促LPO在紫外线辐射下膜功能的变化中起重要作用。暗非酶促LPO对紫外线红斑的发展很重要。环氧化酶LPO可能是紫外线照射血液具有治疗特性的原因。
