Iakovlev V A, Vytrishchak V V, Kharitonov M A
Ter Arkh. 1994;66(8):39-42.
Mechanisms of therapeutic action of UV blood irradiation and optimal irradiation scheduling were studied in the course of UV-irradiated blood transfusions capable of correcting lipid peroxidation (LPO) and antioxidant system (AOS) in acute pneumonia (AP) patients. Single and multiple measurements of LPO and AOS parameters (malonic dialdehyde, diene conjugates, red cell resistance to peroxide hemolysis, catalase, superoxide dismutase, cerulloplasmin, plasma total estrogens, progesterone and testosterone) were made in 10 young males with moderate AP and 20 healthy controls. UV blood irradiation in AP is shown to be pathogenetically validated. It works via effective stabilization of LPO as a result of early adequate stimulation of endogenic AOS. Positive changes were also induced in the system of hormonal regulation. It is suggested that hyperestrogenemia plays a compensatory role in AP pathogenesis.
在能够纠正急性肺炎（AP）患者脂质过氧化（LPO）和抗氧化系统（AOS）的紫外线照射输血过程中，研究了紫外线血液照射的治疗作用机制和最佳照射方案。对10例中度AP的年轻男性患者和20名健康对照者进行了LPO和AOS参数（丙二醛、二烯共轭物、红细胞对过氧化物溶血的抵抗力、过氧化氢酶、超氧化物歧化酶、铜蓝蛋白、血浆总雌激素、孕酮和睾酮）的单次和多次测量。结果表明，AP患者的紫外线血液照射具有病理生理学依据。它通过早期充分刺激内源性AOS，有效稳定LPO而起作用。激素调节系统也出现了积极变化。提示高雌激素血症在AP发病机制中起代偿作用。
