通过2-炔基苯甲醛、胺、锌与烯丙基溴或苄基溴的多组分一锅法反应合成功能化的1,2-二氢异喹啉。

Synthesis of functionalized 1,2-dihydroisoquinolines via multicomponent one-pot reaction of 2-alkynylbenzaldehyde, amine, zinc, and allylic bromide or benzyl bromide.

作者信息

Gao Ke, Wu Jie

机构信息

Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China.

出版信息

J Org Chem. 2007 Oct 26;72(22):8611-3. doi: 10.1021/jo7016839. Epub 2007 Oct 6.

DOI:10.1021/jo7016839

PMID:17919003

Abstract

A multicomponent one-pot reaction of 2-alkynylbenzaldehydes, amines, zinc, and allylic bromide or benzyl bromide using the combination of Mg(ClO4)2/Cu(OTf)2 as catalyst in THF/DCE (1:20) is described, which provides an efficient and practical route for the synthesis of functionalized 1,2-dihydroisoquinolines.

摘要

描述了一种使用Mg(ClO4)2/Cu(OTf)2作为催化剂，在THF/DCE（1:20）中，使2-炔基苯甲醛、胺、锌与烯丙基溴或苄基溴发生多组分一锅法反应，该反应为合成功能化的1,2-二氢异喹啉提供了一条高效且实用的路线。