通过三氟甲磺酸银催化的2-炔基苯甲醛、胺和吲哚的三组分反应合成1-(1H-吲哚-3-基)-1,2-二氢异喹啉。
Synthesis of 1-(1H-indol-3-yl)-1,2-dihydroisoquinolines via AgOTf-catalyzed three-component reactions of 2-alkynylbenzaldehydes, amines, and indoles.
作者信息
Yu Xingxin, Wu Jie
机构信息
Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China.
出版信息
J Comb Chem. 2010 Mar 8;12(2):238-44. doi: 10.1021/cc9001263.
PMID:20058905
Abstract
Three-component reactions of 2-alkynylbenzaldehydes, amines, and indoles catalyzed by AgOTf under mild conditions afford the 1-(1H-indol-3-yl)-1,2-dihydroisoquinolines in good yields. This silver-catalyzed tandem reaction is found to be workable with various indoles, anilines or alkyl amines, and 2-alkynylbenzaldehydes with electron-withdrawing groups attached on the aromatic backbone.
摘要
在温和条件下，由三氟甲磺酸银催化的2-炔基苯甲醛、胺和吲哚的三组分反应能以良好的产率得到1-(1H-吲哚-3-基)-1,2-二氢异喹啉。人们发现，这种银催化的串联反应适用于各种吲哚、苯胺或烷基胺，以及在芳环骨架上带有吸电子基团的2-炔基苯甲醛。
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