啮齿动物用于衰老研究时更标准化病毒学特征描述的必要性。
Necessity of a more standardized virological characterization of rodents for aging studies.
作者信息
van der Logt J T
机构信息
Department of Medical Microbiology, University of Nijmegen, The Netherlands.
出版信息
Neurobiol Aging. 1991 Nov-Dec;12(6):669-72. doi: 10.1016/0197-4580(91)90119-5.
Characterization of the microbiological status is an important facet of a quality assurance program for laboratory animals. This paper addresses basic issues with regard to standardization of the characterization of murine viral status. Methods for such characterization include clinical signs, virus isolation, and serological tests. Significant considerations are screening profiles; sample collection, processing, and shipment; and sampling schedules. International standardization of programs and methods to control and characterize the microbiological status of laboratory animals is being developed, and will be highly significant in future efforts to produce, control, and maintain laboratory animals free of viral infections.
微生物学状态的鉴定是实验动物质量保证计划的一个重要方面。本文探讨了关于小鼠病毒状态鉴定标准化的基本问题。此类鉴定方法包括临床症状、病毒分离和血清学检测。重要的考虑因素有筛查方案；样本采集、处理和运输；以及采样计划。控制和鉴定实验动物微生物学状态的计划和方法的国际标准化正在制定中，这对于未来生产、控制和维持无病毒感染的实验动物的努力将具有重大意义。
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