Diagne Christophe A, Charbonnel Nathalie, Henttonen Heikki, Sironen Tarja, Brouat Carine
1 CBGP, IRD, CIRAD, INRA, Montpellier SupAgro, University of Montpellier , Montpellier, France .
2 BIOPASS (IRD-CBGP, ISRA, UCAD), Dakar, Senegal .
Vector Borne Zoonotic Dis. 2017 Oct;17(10):730-733. doi: 10.1089/vbz.2017.2135. Epub 2017 Sep 5.
Increasing studies on rodent-borne diseases still highlight the major role of rodents as reservoirs of numerous zoonoses of which the frequency is likely to increase worldwide as a result of accelerated anthropogenic changes, including biological invasions. Such a situation makes pathogen detection in rodent populations important, especially in the context of developing countries characterized by high infectious disease burden. Here, we used indirect fluorescent antibody tests to describe the circulation of potentially zoonotic viruses in both invasive (Mus musculus domesticus and Rattus rattus) and native (Mastomys erythroleucus and Mastomys natalensis) murine rodent populations in Senegal (West Africa). Of the 672 rodents tested, we reported 22 seropositive tests for Hantavirus, Orthopoxvirus, and Mammarenavirus genera, and no evidence of viral coinfection. This study is the first to report serological detection of Orthopoxvirus in rodents from Senegal, Mammarenavirus in R. rattus from Africa, and Hantavirus in M. m. domesticus and in M. erythroleucus. Further specific identification of the viral agents highlighted here is urgently needed for crucial public health concerns.
对啮齿动物传播疾病的研究日益增多，这仍凸显了啮齿动物作为众多人畜共患病宿主的主要作用。由于包括生物入侵在内的加速的人为变化，这些人畜共患病在全球的发生频率可能会增加。这种情况使得在啮齿动物种群中检测病原体变得很重要，特别是在以高传染病负担为特征的发展中国家背景下。在这里，我们使用间接荧光抗体试验来描述在塞内加尔（西非）的入侵鼠类（家小家鼠和黑家鼠）和本地鼠类（红背肥鼠和南非肥鼠）种群中潜在人畜共患病毒的传播情况。在检测的672只啮齿动物中，我们报告了22例针对汉坦病毒属、正痘病毒属和沙粒病毒属的血清学阳性检测结果，且没有病毒合并感染的证据。本研究首次报告了在塞内加尔啮齿动物中对正痘病毒的血清学检测、在非洲黑家鼠中对沙粒病毒的血清学检测，以及在家小家鼠和红背肥鼠中对汉坦病毒的血清学检测。鉴于关键的公共卫生问题，迫切需要对这里突出的病毒病原体进行进一步的特异性鉴定。
