父亲酗酒预示着酒精性饮酒的发生，但不能预示其缓解：一项40年的随访研究。
Paternal alcoholism predicts the occurrence but not the remission of alcoholic drinking: a 40-year follow-up.
作者信息
Knop J, Penick E C, Nickel E J, Mednick S A, Jensen P, Manzardo A M, Gabrielli W F
机构信息
The Institute of Preventive Medicine, University of Copenhagen, Copenhagen, Denmark.
出版信息
Acta Psychiatr Scand. 2007 Nov;116(5):386-93. doi: 10.1111/j.1600-0447.2007.01015.x.
OBJECTIVE
To test the effects of father's alcoholism on the development and remission from alcoholic drinking by age 40.
METHOD
Subjects were selected from a Danish birth cohort that included 223 sons of alcoholic fathers (high risk; HR) and 106 matched controls (low risk; LR). Clinical examinations were performed at age 40 (n = 202) by a psychiatrist using structured interviews and DSM-III-R diagnostic criteria.
RESULTS
HR subjects were significantly more likely than LR subjects to develop alcohol dependence (31% vs. 16%), but not alcohol abuse (17% vs. 15%). More subjects with alcohol abuse were in remission at age 40 than subjects with alcohol dependence. Risk did not predict remission from either alcohol abuse or alcohol dependence.
CONCLUSION
Familial influences may play a stronger role in the development of alcoholism than in the remission or recovery from alcoholism.
目的
测试父亲酗酒对40岁时酒精性饮酒的发展及缓解的影响。
方法
研究对象选自丹麦一个出生队列，其中包括223名酗酒父亲的儿子（高风险；HR）和106名匹配的对照者（低风险；LR）。40岁时（n = 202）由一名精神科医生采用结构化访谈和《精神疾病诊断与统计手册》第三版修订版（DSM-III-R）诊断标准进行临床检查。
结果
HR组对象比LR组对象更易发展为酒精依赖（31%对16%），但酒精滥用情况并非如此（17%对15%）。40岁时，酒精滥用缓解的对象比酒精依赖缓解的对象更多。风险并不能预测酒精滥用或酒精依赖的缓解情况。
结论
家族影响在酒精中毒的发展中可能比在酒精中毒的缓解或康复中发挥更强的作用。
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