欧洲区域11个国家水痘带状疱疹病毒的比较血清流行病学研究。

The comparative sero-epidemiology of varicella zoster virus in 11 countries in the European region.

作者信息

Nardone A, de Ory F, Carton M, Cohen D, van Damme P, Davidkin I, Rota M C, de Melker H, Mossong J, Slacikova M, Tischer A, Andrews N, Berbers G, Gabutti G, Gay N, Jones L, Jokinen S, Kafatos G, de Aragón M V Martínez, Schneider F, Smetana Z, Vargova B, Vranckx R, Miller E

机构信息

Health Protection Agency, Centre for Infections, London, UK.

出版信息

Vaccine. 2007 Nov 7;25(45):7866-72. doi: 10.1016/j.vaccine.2007.07.036. Epub 2007 Aug 8.

DOI:10.1016/j.vaccine.2007.07.036

PMID:17919788

Abstract

The European sero-epidemiology network (ESEN2) aims to standardise serological surveillance of varicella zoster virus (VZV) in 11 participant countries. In each country, serum banks were collected between 1996 and 2003 and tested for VZV antibodies. Assay results were standardised so that international comparisons could be made. Age-specific forces of infection were calculated for three age groups (<5, 5-9 and >or=10 years of age) and used to estimate the base reproduction number (R(0)) and the herd immunity threshold (H). Most VZV infection occurred in childhood, but there was a wide variation in transmissibility, with R(0) ranging from 16.9 in the Netherlands to 3.3 in Italy. Herd immunity thresholds varied from 70% in Italy to 94% in the Netherlands. There are substantial differences in VZV sero-epidemiology within the European region, which will need to be taken into account in designing national policies regarding VZV vaccination.

摘要

欧洲血清流行病学网络（ESEN2）旨在对11个参与国的水痘带状疱疹病毒（VZV）血清学监测进行标准化。在每个国家，于1996年至2003年期间收集血清库并检测VZV抗体。对检测结果进行标准化处理，以便能够进行国际比较。计算了三个年龄组（<5岁、5 - 9岁和≥10岁）的年龄特异性感染率，并用于估计基本再生数（R(0)）和群体免疫阈值（H）。大多数VZV感染发生在儿童期，但传播性存在很大差异，R(0)范围从荷兰的16.9到意大利的3.3。群体免疫阈值从意大利的70%到荷兰的94%不等。欧洲区域内VZV血清流行病学存在显著差异，在制定有关VZV疫苗接种的国家政策时需要考虑到这一点。