Lee Boung-Chul, Yang Jae-Won, Lee So-Hee, Kim Seung-Hyun, Joe Sook-Haeng, Jung In-Kwa, Choi Ihn-Geun, Ham Byung-Joo
Department of Psychiatry, Hangang Sacred Heart Hospital, Hallym University Medical Center, Seoul, South Korea.
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jan 1;32(1):238-42. doi: 10.1016/j.pnpbp.2007.08.014. Epub 2007 Aug 22.
The personality traits associated with the noradrenergic system have not yet been clearly established. In the present study, we investigated the variable number of tandem repeats (VNTR) polymorphism of the norepinephrine transporter (NET) and monoamine oxidase A (MAOA), which are major components of the adrenergic system, to elucidate their relationship with personality. A total of 245 normal female Koreans (age 23.05+/-3.07 years, mean+/-SD) volunteered to take part in this study. They filled out a Korean version of the Temperament and Character Inventory (TCI) and were genotyped for the NET and MAOA-VNTR; the NET T-182C and MAOA-uVNTR polymorphisms were checked. We found significant main effect of NET genotype on novelty seeking (NS) score (F=5.43, p=0.021) and significant interaction between the NET and MAOA-uVNTR polymorphisms on NS score (F=11.06, p=0.001). However, there were no relationship between MAOA-uVNTR polymorphisms and NS score, and no association with other temperamental dimensions and these two polymorphisms. Our findings suggest that this functional polymorphism in the noradrenergic gene is associated with novelty seeking in Korean females.
与去甲肾上腺素能系统相关的人格特质尚未明确确立。在本研究中，我们调查了去甲肾上腺素转运体（NET）和单胺氧化酶A（MAOA）的可变串联重复序列（VNTR）多态性，它们是肾上腺素能系统的主要组成部分，以阐明它们与人格的关系。共有245名正常韩国女性（年龄23.05±3.07岁，平均值±标准差）自愿参与本研究。她们填写了韩文版的气质和性格量表（TCI），并对NET和MAOA-VNTR进行基因分型；检测了NET T-182C和MAOA-uVNTR多态性。我们发现NET基因型对新奇寻求（NS）得分有显著的主效应（F = 5.43，p = 0.021），并且NET和MAOA-uVNTR多态性对NS得分有显著的交互作用（F = 11.06，p = 0.001）。然而，MAOA-uVNTR多态性与NS得分之间没有关系，并且与其他气质维度以及这两种多态性也没有关联。我们的研究结果表明，去甲肾上腺素能基因中的这种功能多态性与韩国女性的新奇寻求有关。
Zotero 插件