Bird Suzanne E, Williams Karen, Kula Katherine
Department of Orthodontics and Dentofacial Orthopedics, School of Dentistry, University of Missouri at Kansas City, Mo 64108-2784, USA.
Am J Orthod Dentofacial Orthop. 2007 Oct;132(4):504-10. doi: 10.1016/j.ajodo.2006.11.019.
Pain control during orthodontics is an important aspect of patient compliance. The aim of this prospective, randomized, double-blind clinical trial was to compare the pain control effectiveness of acetaminophen (650 mg) with ibuprofen (400 mg) taken 1 hour before separator placement in adolescents.
The patients recorded their discomfort on a 100-mm visual analog scale during several activities (teeth not touching, chewing, and fitting back teeth together) and by selecting words adapted from the McGill Pain Questionnaire at 5 time intervals: immediately before separator placement, immediately after separator placement, 2 to 3 hours later, at bedtime, and on awakening the next morning. The patients (n = 33) were randomly assigned to the ibuprofen group or the acetaminophen group. A repeated-measures ANOVA was performed as a function of time and treatment group.
Pain increased immediately after separator placement, lessened, and then increased to a peak the next morning. The most commonly selected words to describe pain were "annoying," "sore," and "tight." There was no significant difference in pain at any time after separator placement regardless of the medication taken.
Acetaminophen and ibuprofen produced no significant differences in pain after separator placement.
正畸治疗期间的疼痛控制是患者依从性的一个重要方面。这项前瞻性、随机、双盲临床试验的目的是比较在青少年放置分离器前1小时服用对乙酰氨基酚(650毫克)和布洛芬(400毫克)的疼痛控制效果。
患者在几种活动期间(牙齿不接触、咀嚼以及后牙咬合),通过在100毫米视觉模拟量表上记录不适程度,并在5个时间点从改编自麦吉尔疼痛问卷的词汇中进行选择:放置分离器前即刻、放置分离器后即刻、2至3小时后、就寝时以及次日早晨醒来时。患者(n = 33)被随机分配到布洛芬组或对乙酰氨基酚组。作为时间和治疗组的函数进行重复测量方差分析。
放置分离器后疼痛立即加剧,随后减轻,然后在次日早晨升至峰值。描述疼痛最常选择的词汇是“恼人的”、“酸痛的”和“紧绷的”。无论服用何种药物,放置分离器后任何时间的疼痛均无显著差异。
放置分离器后,对乙酰氨基酚和布洛芬在疼痛控制方面无显著差异。