Offit Kenneth, Thom Peter
Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Semin Oncol. 2007 Oct;34(5):435-43. doi: 10.1053/j.seminoncol.2007.07.007.
As a result of the increasing effectiveness of cancer screening and preventive interventions, ethical issues, as well as legal liabilities, are increasingly associated with cancer genetic testing. These issues include the possible "duty to warn" relatives of inherited cancer risk, the appropriateness of testing of children and embryos, equity of access to genetics services, and potential harms of testing including the risk of genetic discrimination. An approach to these and other ethical challenges will be presented, drawing not only on recent case law but also on a broader bioethical framework.
由于癌症筛查和预防性干预措施的有效性不断提高,伦理问题以及法律责任与癌症基因检测的关联日益紧密。这些问题包括可能存在的向遗传性癌症风险亲属“发出警告的义务”、对儿童和胚胎进行检测的适当性、获得基因服务的公平性,以及检测的潜在危害,包括基因歧视风险。本文将不仅借鉴近期的判例法,还将依据更广泛的生物伦理框架,提出应对这些及其他伦理挑战的方法。