Offit Kenneth, Thom Peter
Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Cancer Treat Res. 2010;155:1-14. doi: 10.1007/978-1-4419-6033-7_1.
In the wake of efficacious preventive interventions based on hereditary cancer risk assessment, a number of ethical and legal challenges have emerged. These include issues such as appropriate testing of children and embryos, the "duty to warn" relatives about familial risk, reproductive genetic testing, the risk of genetic discrimination, and equitable access to testing. These and other issues will be discussed within the framework of a bioethical model, with reference to recent case law.
基于遗传性癌症风险评估的有效预防干预措施实施后，出现了一些伦理和法律挑战。这些挑战包括对儿童和胚胎进行适当检测、向亲属“告知风险的义务”、生殖基因检测、基因歧视风险以及检测的公平可及性等问题。将在生物伦理模型框架内并参考近期判例法对这些及其他问题进行讨论。
