Vollmer E, Bosse A, Bögeholz J, Roessner A, Blasius S, Fahrenkamp A, Böcker W
Gerhard-Domagk-Institut für Pathologie, Westfälische Wilhelms-Universität Münster, FRG.
Pathol Res Pract. 1991 Dec;187(8):957-62. doi: 10.1016/S0344-0338(11)81067-8.
22 nephrectomy specimens of renal allografts in chronic rejection after periods between 3 and 96 months, were studied immunohistologically. Various cell types in the arterial wall were characterized with antibodies specific against different cells of the mononuclear phagocyte system, against smooth muscle cells, and against differentiating lymphoid cells. In addition, the metabolism of lipoproteins was investigated using appropriate antibodies against several apolipoproteins. Subendothelial plaques of foam cells were found to consist of macrophages in foamy transformation. At the stage of intimal fibrosis the smooth muscle cells are more prominent. Lymphatic infiltration consists almost exclusively of T-lymphocytes. Apolipoprotein analysis reveals deposits of Apo A1, A2 and B1, most of them extracellular. According to these results, it is not only immunologic factors that are involved in arterial wall reactions during chronic transplant arteriopathy, but disorders of the lipoprotein metabolism--probably due to endothelial dysfunction--are also playing an important role like in atherosclerosis.
对22例慢性排斥反应中移植肾切除标本进行了研究，这些标本取自移植后3至96个月期间。采用针对单核吞噬细胞系统不同细胞、平滑肌细胞以及分化淋巴细胞的特异性抗体，对动脉壁中的各种细胞类型进行了表征。此外，使用针对几种载脂蛋白的适当抗体研究了脂蛋白的代谢。发现内膜下泡沫细胞斑块由泡沫样转化的巨噬细胞组成。在内膜纤维化阶段，平滑肌细胞更为突出。淋巴浸润几乎完全由T淋巴细胞组成。载脂蛋白分析显示有载脂蛋白A1、A2和B1的沉积，其中大部分位于细胞外。根据这些结果，在慢性移植性动脉病期间，不仅免疫因素参与动脉壁反应，而且脂蛋白代谢紊乱（可能由于内皮功能障碍）也像在动脉粥样硬化中一样起着重要作用。
