Roessner A, Bögeholz J, Bosse A, Vollmer E, Buchholz E, Winde G, Bründermann H
Verh Dtsch Ges Pathol. 1989;73:242-7.
22 nephrectomy specimens of renal allografts in chronic rejection after 3 months to 96 months were studied immunohistologically. The various cell types in the arterial wall were characterised with specific antibodies against different cells of the mononuclear phagocyte system, against smooth muscle cells, and for differentiating lymphatic cells. In addition, the metabolism of lipoproteins was studied using different antibodies against several apolipoproteins. According to our results, subendothelial plaques of foam cells consist of macrophages in foamy transformation. In the stage of intimal fibrosis, smooth muscle cells are more prominent. Lymphatic infiltration consists almost exclusively of T lymphocytes. Apolipoprotein analysis reveals deposits of Apolipoproteins A1 and B, mostly extracellular. On the whole, these results show that not only immunologic factors are involved in the reaction of the arterial wall in chronic transplant arteriopathy, but that like in atherosclerosis, disorders of lipoprotein metabolism, probably due to endothelial dysfunction, play an important role.
对22个肾移植术后3个月至96个月发生慢性排斥反应的肾切除标本进行了免疫组织学研究。利用针对单核吞噬细胞系统不同细胞、平滑肌细胞以及区分淋巴细胞的特异性抗体，对动脉壁中的各种细胞类型进行了表征。此外，使用针对几种载脂蛋白的不同抗体研究了脂蛋白的代谢。根据我们的结果，泡沫细胞的内皮下斑块由正在发生泡沫样转变的巨噬细胞组成。在内膜纤维化阶段，平滑肌细胞更为突出。淋巴浸润几乎完全由T淋巴细胞组成。载脂蛋白分析显示载脂蛋白A1和B的沉积，大多位于细胞外。总体而言，这些结果表明，不仅免疫因素参与了慢性移植性动脉病中动脉壁的反应，而且与动脉粥样硬化一样，脂蛋白代谢紊乱，可能由于内皮功能障碍，起着重要作用。
