INAD信号支架的动态调节变得一目了然。
Dynamic regulation of the INAD signaling scaffold becomes crystal clear.
作者信息
Montell Craig
机构信息
Departments of Biological Chemistry and Neuroscience, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
出版信息
Cell. 2007 Oct 5;131(1):19-21. doi: 10.1016/j.cell.2007.09.022.
PDZ domains are common building blocks of scaffold proteins that enhance specificity and speed in signal transduction cascades. Although PDZ modules are often viewed as passive participants, Mishra et al. (2007) now show that a PDZ domain in INAD, a scaffold protein in photoreceptor cells of the fruit fly, undergoes a light-dependent conformational change, which has important consequences for signaling and animal behavior.
PDZ结构域是支架蛋白的常见组成部分，可增强信号转导级联反应的特异性和速度。尽管PDZ模块通常被视为被动参与者，但米什拉等人（2007年）现在表明，果蝇光感受器细胞中的支架蛋白INAD中的一个PDZ结构域会发生光依赖性构象变化，这对信号传导和动物行为具有重要影响。
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