在非糖尿病高血压患者中，血红蛋白和血浆蛋白糖基化增强与脂质过氧化物水平升高有关。
Enhanced glycation of hemoglobin and plasma proteins is associated with increased lipid peroxide levels in non-diabetic hypertensive subjects.
作者信息
Sathiyapriya Viswanathan, Selvaraj Nambiar, Nandeesha Hanumanthappa, Bobby Zachariah, Agrawal Aparna, Pavithran Purushothaman
机构信息
Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
出版信息
Arch Med Res. 2007 Nov;38(8):822-6. doi: 10.1016/j.arcmed.2007.05.008. Epub 2007 Aug 23.
BACKGROUND
Accumulating evidences indicate that lipid peroxidation and protein glycation play a vital role in the pathogenesis of cardiovascular disease. The purpose of the present study was to evaluate the levels of lipid peroxides and glycated proteins in non-diabetic hypertensive patients and to assess the possible nexus between them, among these subjects.
METHODS
Thirty hypertensive patients and 25 normotensive subjects were enrolled in the present study. Lipid peroxides, glycated hemoglobin, and fructosamine levels were estimated in both groups.
RESULTS
Lipid peroxides, glycated hemoglobin, and fructosamine levels were significantly increased in hypertensive subjects in comparison with normotensive subjects. When partial correlation analysis was performed, malondialdehyde was significantly associated with glycated hemoglobin and fructosamine.
CONCLUSIONS
An increased glycation of proteins was found in non-diabetic hypertensive subjects. These data also support the premise that lipid peroxidation per se plays a role in glycation of hemoglobin and plasma proteins.
背景
越来越多的证据表明，脂质过氧化和蛋白质糖基化在心血管疾病的发病机制中起着至关重要的作用。本研究的目的是评估非糖尿病高血压患者中脂质过氧化物和糖基化蛋白的水平，并评估这些受试者中它们之间可能存在的联系。
方法
本研究纳入了30例高血压患者和25例血压正常的受试者。对两组患者的脂质过氧化物、糖化血红蛋白和果糖胺水平进行了评估。
结果
与血压正常的受试者相比，高血压受试者的脂质过氧化物、糖化血红蛋白和果糖胺水平显著升高。进行偏相关分析时，丙二醛与糖化血红蛋白和果糖胺显著相关。
结论
在非糖尿病高血压受试者中发现蛋白质糖基化增加。这些数据也支持脂质过氧化本身在血红蛋白和血浆蛋白糖基化中起作用这一前提。
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