Rudofsky G, Schlotterer A, Humpert P M, Tafel J, Morcos M, Nawroth P P, Bierhaus A, Hamann A
Division of Endocrinology and Metabolism, Department of Medicine, University of Heidelberg, Germany.
Exp Clin Endocrinol Diabetes. 2008 Jan;116(1):14-7. doi: 10.1055/s-2007-985357. Epub 2007 Oct 9.
We studied the association between a functionally relevant M55V polymorphism in the SUMO4 gene with microvascular diabetic complications in patients with type 1 diabetes.
223 patients with type 1 diabetes were studied using polymerase chain reaction and subsequent cleavage by restriction endonucleases for the M55V SUMO4 gene variant.
No effect of the polymorphism on diabetic neuropathy or diabetic nephropathy was found, but heterozygous or homozygous patients for the M55V polymorphism in the SUMO4 gene had a markedly reduced prevalence of diabetic retinopathy (odds ratio 0.37, 95%-confidence interval (CI) [0.32;0.43]; p=0.004). Furthermore, a multiple logistic regression model showed an age and diabetes duration independent effect of the M55V polymorphisms on the prevalence of diabetic retinopathy (p=0.03), but not of diabetic neuropathy or nephropathy.
Our data indicate that the M55V polymorphism in the SUMO4 gene is associated with a reduced risk of diabetic retinopathy in type 1 diabetes. Thus, the results of our study suggest that posttranslational modification of proteins via SUMO4 could contribute to the development of certain diabetic complications.
我们研究了SUMO4基因中具有功能相关性的M55V多态性与1型糖尿病患者微血管糖尿病并发症之间的关联。
对223例1型糖尿病患者使用聚合酶链反应及随后用限制性内切酶切割来研究M55V SUMO4基因变异。
未发现该多态性对糖尿病神经病变或糖尿病肾病有影响,但SUMO4基因中M55V多态性的杂合子或纯合子患者糖尿病视网膜病变的患病率显著降低(优势比0.37,95%置信区间[CI][0.32;0.43];p = 0.004)。此外,多元逻辑回归模型显示M55V多态性对糖尿病视网膜病变的患病率有独立于年龄和糖尿病病程的影响(p = 0.03),但对糖尿病神经病变或肾病无此影响。
我们的数据表明SUMO4基因中的M55V多态性与1型糖尿病患者糖尿病视网膜病变风险降低有关。因此,我们的研究结果提示通过SUMO4对蛋白质进行翻译后修饰可能有助于某些糖尿病并发症的发生发展。