对 1 型糖尿病患者同胞对家系中 SUMO4/IDDM5 区域内多个单核苷酸多态性的分析。
Analyses of multiple single-nucleotide polymorphisms in the SUMO4/IDDM5 region in affected sib-pair families with type I diabetes.
机构信息
Center for Biotechnology and Genomic Medicine, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA.
出版信息
Genes Immun. 2009 Dec;10 Suppl 1(Suppl 1):S16-20. doi: 10.1038/gene.2009.86.
Abstract
Previous studies suggested that the SUMO4 gene, located in the IDDM5 interval on chromosome 6q25, was associated with type I diabetes (T1D) and several other autoimmune diseases. Subsequent analyses of the SUMO4 variants with T1D suggested that the association was stronger and more consistent in the Asian populations. In addition, considerable heterogeneity has been observed in the Caucasian populations. In this report, a 40-kb genomic interval including the SUMO4 gene was tagged with 15 single-nucleotide polymorphisms. A total of 2317 affected sib-pair families from the Type I Diabetes Genetic Consortium were genotyped using both the Illumina and Sequenom genotyping platforms. In these Caucasian families, we found little evidence supporting an association between SUMO4 and T1D.
摘要
先前的研究表明，位于 6q25 染色体 IDDM5 区间的 SUMO4 基因与 1 型糖尿病（T1D）和其他几种自身免疫性疾病有关。随后对 T1D 的 SUMO4 变体进行的分析表明，这种关联在亚洲人群中更强且更一致。此外，在白人群体中观察到相当大的异质性。在本报告中，用 15 个单核苷酸多态性标记了包含 SUMO4 基因的 40kb 基因组间隔。使用 Illumina 和 Sequenom 基因分型平台对来自 1 型糖尿病遗传联合会的 2317 个受影响的同胞对家族进行了基因分型。在这些白人群体中，我们几乎没有发现支持 SUMO4 与 T1D 之间存在关联的证据。
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