Sugimori Satoshi, Watanabe Toshio, Shiba Masatsugu, Higuchi Kazuhide, Arakawa Tetsuo
Department of Gastroenterology, Osaka City University Graduate School of Medicine.
Nihon Rinsho. 2007 Oct;65(10):1862-5.
Various factors have been shown to be involved in the pathophysiology of NSAID-induced small intestinal damage. Recent advances in diagnostic methods including video capsule endoscopy and double-balloon endoscopy have enabled us to examine the entire small intestine, and we now recognize that prevalence of small intestinal damage in patients taking NSAIDs is high. NSAIDs cause intestinal damage including redness, erosions, and ulcers in both jejunum and ileum. Most of patients with intestinal pathology are asymptomatic, although a few patients present with iron deficiency anemia and/or hypoalbuminaemia. The risk factors for NSAID-induced enteropathy are unknown. Experimental and clinical studies would unravel the mechanism by which NSAIDs injure intestinal mucosa.
多种因素已被证明与非甾体抗炎药（NSAID）所致小肠损伤的病理生理学有关。包括视频胶囊内镜和双气囊内镜在内的诊断方法的最新进展使我们能够检查整个小肠，并且我们现在认识到服用NSAIDs的患者中小肠损伤的患病率很高。NSAIDs会导致空肠和回肠出现包括发红、糜烂和溃疡在内的肠道损伤。大多数肠道病变患者没有症状，尽管少数患者会出现缺铁性贫血和/或低白蛋白血症。NSAID所致肠病的危险因素尚不清楚。实验和临床研究将阐明NSAIDs损伤肠黏膜的机制。
