Motor Sedat, Alp Harun, Senol Serkan, Pınar Neslihan, Motor Vicdan Köksaldı, Kaplan Ibrahim, Alp Ayşe, Gökçe Cumali
Department of Biochemistry, School of Medicine, Mustafa Kemal University Hatay, Turkey.
Department of Pharmacology, School of Medicine, Mustafa Kemal University Hatay, Turkey.
Int J Clin Exp Med. 2014 Apr 15;7(4):1005-13. eCollection 2014.
This study was aimed to comparison of the effects of the chronic use of the Ribavirin and caffeic acid phenethyl ester (CAPE) on the pancreatic damage and hepatotoxicity in rats.
The rats were given orally 30 mg/kg/day doses of Ribavirin for 30 days, and intraperitoneally 10 μmol/kg doses of CAPE. The 37 rats were divided into 4 groups: (I) Control (n=7), (II) Ribavirin (R) (n=10), (III) CAPE (n=10), and (IV) R+CAPE (n=10).
Ribavirin and CAPE yielded similar results in terms of Serum, total antioxidant status (TAS), total oxidant status (TOS), amylase, lipase, and insulin compared to the control group. However, while Ribavirin provided similar results with the control group in terms of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) enzymes, the CAPE group had elevated AST and ALT levels compared to the control group. Histopathologic evaluations revealed that CAPE or Ribavirin had no degenerative effects on both the pancreas and liver tissues. In this way, the biochemical results were confirmed by the histopathologic results.
It can be concluded that Ribavirin does not lead to any pancreatic damage and hepatotoxicity, and has more beneficial effects than CAPE on especially liver tissue.
本研究旨在比较长期使用利巴韦林和咖啡酸苯乙酯（CAPE）对大鼠胰腺损伤和肝毒性的影响。
给大鼠口服30mg/kg/天剂量的利巴韦林，持续30天，腹腔注射10μmol/kg剂量的CAPE。37只大鼠分为4组：（I）对照组（n = 7），（II）利巴韦林组（R）（n = 10），（III）CAPE组（n = 10），以及（IV）R + CAPE组（n = 10）。
与对照组相比，利巴韦林和CAPE在血清、总抗氧化状态（TAS）、总氧化状态（TOS）、淀粉酶、脂肪酶和胰岛素方面产生了相似的结果。然而，虽然利巴韦林在天冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT）酶方面与对照组结果相似，但CAPE组的AST和ALT水平高于对照组。组织病理学评估显示，CAPE或利巴韦林对胰腺和肝脏组织均无退行性影响。通过这种方式，组织病理学结果证实了生化结果。
可以得出结论，利巴韦林不会导致任何胰腺损伤和肝毒性，并且对特别是肝脏组织的有益作用比CAPE更多。
