癫痫发作中的遗传因素：来自大量双胞胎群体的证据。

Genetic factors in epileptic seizures: evidence from a large twin population.

作者信息

Sillanpää M, Koskenvuo M, Romanov K, Kaprio J

机构信息

Department of Child Neurology, Turku University Hospital, Finland.

出版信息

Acta Neurol Scand. 1991 Dec;84(6):523-6. doi: 10.1111/j.1600-0404.1991.tb05886.x.

DOI:10.1111/j.1600-0404.1991.tb05886.x

PMID:1792856

Abstract

The Finnish Twin Cohort study (27,776 individuals; all twins of the same sex born before 1958 and alive in 1967) detected 316 cases of epileptic seizures occurring in 310 twin pairs: 89 monozygotic pairs and 221 dizygotic pairs, including three concordant monozygotic pairs and three concordant dizygotic pairs. The ratio of the observed to expected number of concordant pairs for epileptic seizures was 5.48 (90% CL 1.5-14.2) in monozygotic and 2.12 (90% CL 0.6-5.5) in dizygotic pairs. The results suggest that 8% to 27% of the incidence of epileptic seizures is related to genetic variability. The study of environmental differences in discordant monozygotic pairs should provide insights into the etiology of this group of disorders.

摘要

芬兰双胞胎队列研究（27776人；1958年以前出生且1967年仍在世的所有同性双胞胎）在310对双胞胎中检测到316例癫痫发作病例：89对同卵双胞胎和221对异卵双胞胎，其中包括3对同卵双胞胎和3对异卵双胞胎癫痫发作一致。癫痫发作一致对的观察数与预期数之比在同卵双胞胎中为5.48（90%可信区间1.5 - 14.2），在异卵双胞胎中为2.12（90%可信区间0.6 - 5.5）。结果表明，8%至27%的癫痫发作发病率与基因变异有关。对不一致的同卵双胞胎环境差异的研究应能为这组疾病的病因提供见解。