Kjeldsen Marianne J, Corey Linda A, Solaas Marit H, Friis Mogens L, Harris Jennifer R, Kyvik Kirsten O, Christensen Kaare, Pellock John M
The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark.
Twin Res Hum Genet. 2005 Apr;8(2):138-47. doi: 10.1375/1832427053738836.
The purpose of the study was to describe a large sample of twins reporting a history of seizures, to characterize seizures in the three subpopulations, and to estimate the relative importance of genetic and environmental factors in seizure occurrence. Seizure history was determined by questionnaires completed by twins in population-based twin registries in the United States, Norway and Denmark. Concordance rates were calculated for all seizure categories within and across twin populations. Of 47,626 twin pairs evaluated, 6234 reported a history of seizures in one or both twins. Concordance rates were significantly higher for monozygotic (MZ) versus dizygotic (DZ)pairs for all seizure categories within and across populations. The results of this study involving the largest unselected, population-based sample of twins with seizures assembled to date confirm the importance of genetic factors in determining risk for epilepsy, febrile seizures, other seizures and staring spells. This sample is likely to provide an important resource for studying the genetics of epilepsy subtypes and febrile seizures.
该研究的目的是描述报告有癫痫发作史的大量双胞胎样本，对三个亚群体中的癫痫发作进行特征描述，并估计遗传和环境因素在癫痫发作发生中的相对重要性。癫痫发作史通过美国、挪威和丹麦基于人群的双胞胎登记处的双胞胎填写的问卷来确定。计算了双胞胎群体内部和之间所有癫痫发作类别的一致性率。在评估的47626对双胞胎中，6234对报告其中一个或两个双胞胎有癫痫发作史。在群体内部和之间，所有癫痫发作类别的单卵双胞胎（MZ）与双卵双胞胎（DZ）的一致性率显著更高。这项涉及迄今为止收集到的最大的未经选择的、基于人群的有癫痫发作的双胞胎样本的研究结果证实了遗传因素在确定癫痫、热性惊厥、其他癫痫发作和凝视发作风险方面的重要性。该样本可能为研究癫痫亚型和热性惊厥的遗传学提供重要资源。
