Kobayashi Shu, Momohara Shigeki, Ikari Katsunori, Mochizuki Takeshi, Kawamura Koichiro, Tsukahara So, Nishimoto Kazumasa, Okamoto Hiroshi, Tomatsu Taisuke
Department of Orthopedic Surgery, Institute of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada, Shinjuku-ku, Tokyo, 162-0054, Japan.
Mod Rheumatol. 2007;17(5):418-21. doi: 10.1007/s10165-007-0599-2. Epub 2007 Oct 19.
Castleman's disease (CD), diffuse idiopathic skeletal hyperostosis (DISH), and ossification of the posterior longitudinal ligament of the spine (OPLL) are three different entities. Castleman's disease displaying a variety of calcifications in the abdomen and/or pelvis has been reported in some papers. However, there were no reports suggesting an association between CD and ossification/calcification in spine and joints. So far, there has been no case report regarding the coexistence of these diseases in the literature. Herein, we detail a 75-year-old man suffering from CD who demonstrated the features of DISH with coexisting features of OPLL. The cardinal symptoms such as fatigue, high fever, and swollen glands in this case were reduced by corticosteroid therapy. However, it is possible to produce actual symptoms of ossifying/calcified diathesis of entheses and ligaments as a consequence, like the pathology of calcification found in the region of the spleen. In this paper, we describe this patient in order to discuss the association of these diseases.
卡斯特曼病（CD）、弥漫性特发性骨肥厚（DISH）和脊柱后纵韧带骨化（OPLL）是三种不同的病症。一些论文报道过卡斯特曼病在腹部和/或骨盆出现多种钙化。然而，尚无报道表明CD与脊柱和关节的骨化/钙化之间存在关联。迄今为止，文献中尚无关于这些疾病共存的病例报告。在此，我们详细介绍一名75岁患有CD的男性，其表现出DISH的特征并伴有OPLL的共存特征。该病例中诸如疲劳、高热和腺体肿大等主要症状通过皮质类固醇治疗得到缓解。然而，结果可能会产生诸如在脾脏区域发现的钙化病理那样的肌腱和韧带骨化/钙化素质的实际症状。在本文中，我们描述该患者以探讨这些疾病之间的关联。
