阿司匹林和地塞米松对单纯疱疹病毒所致原发性葡萄膜炎眼压的影响。

Effect of aspirin and dexamethasone on intraocular pressure in primary uveitis produced by Herpes simplex virus.

作者信息

Marsettio M, Siverio C E, Oh J O

出版信息

Am J Ophthalmol. 1976 May;81(5):636-41. doi: 10.1016/0002-9394(76)90130-6.

Abstract

The intracameral injection of New Zealand white male rabbits with type 1 herpes simplex virus produced acute anterior uveitis with biphasic elevation of the intraocular pressure (IOP). The first IOP increase occurred on day 1 and 2 and the second increase on day 8. There was no significant correlation between the IOP changes and multiplication of herpes simplex virus in the uvea and cornea, nor between the IOP changes and histopathologic alteration of the tissue. Aspirin suppressed significantly the first as well as the second IOP elevation, whereas dexamethasone suppressed significantly only the second elevation.

摘要

向新西兰雄性白兔前房内注射1型单纯疱疹病毒可导致急性前葡萄膜炎，并伴有眼压（IOP）的双相升高。第一次眼压升高发生在第1天和第2天，第二次升高发生在第8天。眼压变化与葡萄膜和角膜中单纯疱疹病毒的增殖之间，以及眼压变化与组织的组织病理学改变之间均无显著相关性。阿司匹林可显著抑制第一次和第二次眼压升高，而地塞米松仅能显著抑制第二次眼压升高。