Richter G W
Am J Pathol. 1976 Apr;83(1):135-48.
Characteristic cytoplasmic and intranuclear fibrillar bodies were produced, within 24 hours, in epithelial cells of the proximal convoluted renal tubules of rats and mice by injecting a single dose of lead acetate either intraperitoneally (100 mug Pb/g) or into the heart (10 mug Pb/g). The frequency of cytoplasmic fibrillar bodies (CFB) rose during the first 4 days following injection of lead and diminished thereafter. Ten days after intracardiac injection of lead no CFB were found; 10 days after intraperitoneal injection, they were still present, though probably in diminished number. Disappearance of CFB may be related to autophagocytosis. Intranuclear fibrillar bodies did not disappear, perhaps because nuclei lack a lysosomal apparatus. Within the first 3 days after injection of lead, clusters or paracrystalline arrays of ferritin molecules were frequently situated in the immediate vicinity of CRB or abutted against CFB; after the third day, little or no ferritin was found near CFB. Intramuscular injection of iron-dextran complex (50 mg Fe/ml) 24 hours prior to intraperitoneal administration of lead did not increase incidence or size of ferritin clusters in the vicinity of CFB in rats. The presence of ferritin near CFB may have been an indirect consequence of inhibition, by lead, of synthesis of heme prosthetic groups.
通过腹腔注射（100微克铅/克）或心脏注射（10微克铅/克）单剂量醋酸铅，在24小时内可在大鼠和小鼠近曲肾小管的上皮细胞中产生特征性的细胞质和核内纤维状小体。细胞质纤维状小体（CFB）的频率在注射铅后的前4天上升，此后下降。心脏内注射铅10天后未发现CFB；腹腔注射10天后，它们仍然存在，尽管数量可能减少。CFB的消失可能与自噬作用有关。核内纤维状小体没有消失，可能是因为细胞核缺乏溶酶体装置。在注射铅后的前3天内，铁蛋白分子簇或平行排列经常位于CFB附近或与CFB相邻；第三天后，在CFB附近几乎没有发现铁蛋白。在腹腔注射铅前24小时肌肉注射右旋糖酐铁复合物（50毫克铁/毫升），并不会增加大鼠CFB附近铁蛋白簇的发生率或大小。CFB附近铁蛋白的存在可能是铅抑制血红素辅基合成的间接结果。
