大鼠摄入铅后，肾近端小管各节段细胞核内包涵体的早期出现及定位

Murakami M, Kawamura R, Nishii S, Katsunuma H

Br J Exp Pathol. 1983 Apr;64(2):144-55.

Intranuclear inclusions in epithelial cells lining rat renal proximal tubules were detected by electron microscopy as early as 4 days after the addition of lead (5 mg/ml as lead acetate) to the drinking water. At 9 and 12 weeks pathological changes, but very few intranuclear inclusions, were apparent in the epithelial cells lining the third segment of the proximal tubules in the outer stripe of outer zone of the medulla. On the other hand, morphological changes were less in the epithelial cells lining the first and second segments of the proximal tubules in the cortex, which contained many intranuclear inclusions. These findings suggest that lead incorporated into the epithelial cells in the proximal tubules may exist in an inert chemical form as inclusions, especially in the second segment. These bodies, therefore, may protect the cells from the toxic effect of lead.

早在给大鼠饮用水中添加铅（以醋酸铅形式，浓度为5毫克/毫升）4天后，通过电子显微镜就检测到大鼠肾近端小管内衬上皮细胞中的核内包涵体。在9周和12周时，髓质外带近端小管第三段内衬的上皮细胞出现了病理变化，但核内包涵体很少。另一方面，皮质近端小管第一段和第二段内衬的上皮细胞形态变化较小，其中含有许多核内包涵体。这些发现表明，进入近端小管上皮细胞的铅可能以包涵体的形式以惰性化学形式存在，尤其是在第二段。因此，这些包涵体可能保护细胞免受铅的毒性作用。