Ek Sara, Dictor Michael, Jerkeman Mats, Jirström Karin, Borrebaeck Carl A K
Department of Immunotechnology, CREATE Health, BioMedical Center, Lund University, and Department of Pathology, Lund University Hospital, Sweden.
Blood. 2008 Jan 15;111(2):800-5. doi: 10.1182/blood-2007-06-093401. Epub 2007 Oct 12.
Mantle cell lymphoma (MCL) is defined pathologically by the detection of CD20, CD5, and most importantly cyclin D1 (CCND1). Its distinction from other lymphomas is important for prognosis and appropriate therapy, but occasional cases may fail to express CCND1 and morphologic simulators may express CD20 and CD5 but not CD23. In this study, we show that the transcription factor Sox11 is specifically expressed in the nucleus of MCL compared with other lymphomas and benign lymphoid tissue. Although the role of Sox11 presently is not known in lymphocyte ontogeny, it is normally expressed in the developing central nervous system in the embryo and shows sequence homology with Sox4, a transcription factor crucial for B lymphopoiesis. Sox11 mRNA is increased in gliomas compared with healthy brain tissue, suggesting a role in malignant transformation and/or cell survival. Our novel finding of specific overexpression of Sox11 mRNA and nuclear protein in both cyclin D1-positive and - negative MCL may be useful for the diagnosis of MCL as a complement to cyclin D1 and also suggests a functional role for Sox11 in MCL.
套细胞淋巴瘤（MCL）在病理上通过检测CD20、CD5以及最重要的细胞周期蛋白D1（CCND1）来定义。它与其他淋巴瘤的区分对于预后和适当治疗很重要，但偶尔会有病例不表达CCND1，且形态学模拟物可能表达CD20和CD5但不表达CD23。在本研究中，我们表明，与其他淋巴瘤和良性淋巴组织相比，转录因子Sox11在MCL细胞核中特异性表达。虽然Sox11目前在淋巴细胞发生中的作用尚不清楚，但它在胚胎发育中的中枢神经系统中正常表达，并且与Sox4具有序列同源性，Sox4是一种对B淋巴细胞生成至关重要的转录因子。与健康脑组织相比，胶质瘤中Sox11 mRNA增加，提示其在恶性转化和/或细胞存活中起作用。我们关于Sox11 mRNA和核蛋白在细胞周期蛋白D1阳性和阴性MCL中均特异性过表达的新发现，可能有助于作为对细胞周期蛋白D1的补充来诊断MCL，也提示Sox11在MCL中具有功能作用。
