Jiang Junqing, Wang Yufei, Sun Mengyu, Luo Xiangyuan, Zhang Zerui, Wang Yijun, Li Siwen, Hu Dian, Zhang Jiaqian, Wu Zhangfan, Chen Xiaoping, Zhang Bixiang, Xu Xiao, Wang Shuai, Xu Shengjun, Huang Wenjie, Xia Limin
Department of Gastroenterology, Institute of Liver and Gastrointestinal Diseases, Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei Province, China.
Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases; Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Clinical Medicine Research Center for Hepatic Surgery of Hubei Province; Key Laboratory of Organ Transplantation, Ministry of Education and Ministry of Public Health, Wuhan, Hubei, 430030, China.
Cell Death Discov. 2024 Feb 9;10(1):67. doi: 10.1038/s41420-024-01834-6.
The sex-determining region Y (SRY)-related high-mobility group (HMG) box (SOX) family, composed of 20 transcription factors, is a conserved family with a highly homologous HMG domain. Due to their crucial role in determining cell fate, the dysregulation of SOX family members is closely associated with tumorigenesis, including tumor invasion, metastasis, proliferation, apoptosis, epithelial-mesenchymal transition, stemness and drug resistance. Despite considerable research to investigate the mechanisms and functions of the SOX family, confusion remains regarding aspects such as the role of the SOX family in tumor immune microenvironment (TIME) and contradictory impacts the SOX family exerts on tumors. This review summarizes the physiological function of the SOX family and their multiple roles in tumors, with a focus on the relationship between the SOX family and TIME, aiming to propose their potential role in cancer and promising methods for treatment.
性别决定区Y（SRY）相关高迁移率族（HMG）盒（SOX）家族由20种转录因子组成，是一个具有高度同源HMG结构域的保守家族。由于它们在决定细胞命运中起关键作用，SOX家族成员的失调与肿瘤发生密切相关，包括肿瘤侵袭、转移、增殖、凋亡、上皮-间质转化、干性和耐药性。尽管对SOX家族的机制和功能进行了大量研究，但在SOX家族在肿瘤免疫微环境（TIME）中的作用以及SOX家族对肿瘤产生的矛盾影响等方面仍存在困惑。本综述总结了SOX家族的生理功能及其在肿瘤中的多种作用，重点关注SOX家族与TIME的关系，旨在提出它们在癌症中的潜在作用和有前景的治疗方法。
