Walsh Fiona, Bracher Simon, Turner Phil, Amyes Sebastian
University of Edinburgh, Edinburgh, UK.
Chemotherapy. 2007;53(6):407-9. doi: 10.1159/000109815. Epub 2007 Oct 15.
Mixed populations of Pseudomonas aeruginosa, comprising a carbapenem-susceptible and a carbapenem-resistant strain, containing either the IMP or VIM beta-lactamases, were exposed to imipenem. They developed resistance to both imipenem and meropenem. When the same mixed populations were exposed to meropenem, only the mixture containing the VIM beta-lactamases became resistant to both carbapenems.
包含对碳青霉烯敏感菌株和对碳青霉烯耐药菌株的铜绿假单胞菌混合群体，其中耐药菌株含有IMP或VIMβ-内酰胺酶，将其暴露于亚胺培南。它们对亚胺培南和美罗培南均产生了耐药性。当相同的混合群体暴露于美罗培南时，只有含有VIMβ-内酰胺酶的混合物对两种碳青霉烯类药物都产生了耐药性。
