Fukunaga-Kalabis Mizuho, Herlyn Meenhard
Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
J Invest Dermatol. 2007 Nov;127(11):2497-8. doi: 10.1038/sj.jid.5701050.
The matricellular protein SPARC (secreted protein acidic and rich in cysteine) has diverse functions in melanoma cells. Because this secreted protein is produced not only in tumor cells but also in stromal cells, the question has been asked whether paracrine effects of stroma-derived SPARC contribute to melanoma progression. In this issue, Prada et al. (2007) begin to answer this question by demonstrating that SPARC produced by melanoma, but not stromal cells, is essential to regulate melanoma cell growth.
基质细胞蛋白SPARC（富含半胱氨酸的酸性分泌蛋白）在黑色素瘤细胞中具有多种功能。由于这种分泌蛋白不仅在肿瘤细胞中产生，也在基质细胞中产生，因此有人提出疑问，即基质来源的SPARC的旁分泌作用是否有助于黑色素瘤的进展。在本期杂志中，普拉达等人（2007年）通过证明黑色素瘤而非基质细胞产生的SPARC对调节黑色素瘤细胞生长至关重要，开始回答这个问题。
