Synthesis and evaluation of in vitro antitumor activity of some substituted 5-pyridazinyl-styrylketones.

A series of twenty pyridazinyl-styrilketones, substituted at position 4 with linear or cyclic tertiary amino groups, were synthesized and evaluated in vitro as antitumor agents against 60 human tumor cell-lines. Moderate activity and differential cell sensitivity were found for several of the compounds. Cell-line XF-498L (panel:Brain) showed differential cell sensitivity towards compound 5b (more than 1000 times the mean sensitivity of all cell-lines).