新型6-氰基-3-苯基-1,2,3,4-四氢-1,2-二氮杂卓-5-酮：合成及体外抗肿瘤活性评价
New 6-cyano-3-phenyl-1-,2,3,4-tetrahydro-1,2-diazepin-5-ones: synthesis and in vitro antitumor activity evaluation.
作者信息
Dal Piaz V, Ciciani G, Giovannoni M P
机构信息
Dipartimento di Scienze Farmaceutiche, Facoltà di Farmacia, Università di Firenze.
出版信息
Farmaco. 1991 Mar;46(3):435-47.
PMID:1892501
Abstract
A series of 6-cyano-3-phenyl-1,2,3,4-tetrahydro-1,2-diazepin-5-ones were synthesized and evaluated in vitro as antitumor agents against several human tumor cell lines. Moderate activity and differential cellular sensitivity were found for a few of the tested compounds.
摘要
合成了一系列6-氰基-3-苯基-1,2,3,4-四氢-1,2-二氮杂卓-5-酮，并在体外对几种人类肿瘤细胞系作为抗肿瘤剂进行了评估。发现少数测试化合物具有中等活性和不同的细胞敏感性。
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