2-(3-溴-5-异恶唑基亚氨基氧基)乙酰胺基-β-内酰胺衍生物的合成及其体外抗菌性能
Synthesis and in vitro antibacterial properties of 2-(3-bromo-5-isoxazolylideneamino-oxy)acetamido-beta-lactam derivatives.
作者信息
Sala A, Chiarino D, Napoletano M, Albini E, Carenzi A
机构信息
Zambon Research Laboratories, Milano, Italy.
出版信息
Farmaco. 1991 Jul-Aug;46(7-8):887-97.
PMID:1793473
Abstract
The synthesis of new 2-(3-bromo-5-isoxazolylideneamino-oxy)acetic acids and their condensation derivatives with suitable beta-lactam nuclei is reported. Their antibacterial properties have been tested in vitro. An interesting activity against Gram-positive bacteria including beta-lactamase-producing microorganisms was found among the cephalosporanic acid derivatives.
摘要
报道了新型2-(3-溴-5-异恶唑亚基氨基氧基)乙酸及其与合适的β-内酰胺核的缩合衍生物的合成。已对它们的抗菌性能进行了体外测试。在头孢烷酸衍生物中发现了对革兰氏阳性菌包括产β-内酰胺酶微生物的有趣活性。
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