Huang Ke, Tang Wei, Tang Ruqi, Xu Zhao, He Zhangdong, Li Zhiqiang, Xu Yifeng, Li Xingwang, He Guang, Feng Guoying, He Lin, Shi Yongyong
Bio-X Center, Shanghai Jiao Tong University, PO Box 501, Haoran Building, 1954 Huashan Road, Shanghai, 200030, People's Republic of China.
Hum Genet. 2008 Jan;122(6):659-60. doi: 10.1007/s00439-007-0434-z. Epub 2007 Oct 13.
A recent study reported that OLIG2 had a significant association with schizophrenia in the UK population. We genotyped three variants scattered among the genomic region of OLIG2, namely rs1005573, rs762178 and rs1059004 in a sample consisting of 329 schizophrenia patients and 288 controls. The results provide further evidence that the SNP rs762178 in OLIG2 seems to be a potential candidate in altering risk for schizophrenia in the Chinese Han population and worthy of further replication and functional study.
最近一项研究报告称，在英国人群中，少突胶质细胞转录因子2（OLIG2）与精神分裂症存在显著关联。我们对329例精神分裂症患者和288例对照组成的样本中的三个分布于OLIG2基因区域的变体进行了基因分型，即rs1005573、rs762178和rs1059004。结果进一步证明，OLIG2中的单核苷酸多态性（SNP）rs762178似乎是改变中国汉族人群精神分裂症风险的一个潜在候选因素，值得进一步重复研究和功能研究。
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