Department of Ultrasound, The 2nd Affiliated Hospital of Harbin Medical University, NO. 246, Xuefu Road, Nangang District, Harbin, 150081, Heilongjiang, People's Republic of China.
Department of Neurosurgery, The 2nd Affiliated Hospital of Harbin Medical University, NO. 246, Xuefu Road, Nangang District, Harbin, 150081, Heilongjiang, People's Republic of China.
Neuromolecular Med. 2016 Dec;18(4):573-580. doi: 10.1007/s12017-016-8406-x. Epub 2016 May 23.
Ischemic stroke is a common neurological disease and a leading cause of permanent disability in many countries. Recent studies provide evidence on the role of the suppressor of the cytokine signaling 1 (SOCS1) gene in the development and progression of atherosclerotic lesions. However, few studies have assessed the association between single nucleotide polymorphisms (SNPs) on SOCS1 gene and ischemic stroke. Therefore, the present study aimed to investigate the role of SOCS1 polymorphism in ischemic stroke risk in a northern Chinese Han population. We examined 475 patients with ischemic stroke and 486 normal controls. Three SNPs (rs243327, rs243330, and rs33932899) of SOCS1 gene were determined for TaqMan genotyping assays. We also classified these case samples in depth by complications with hypertension or diabetes and by ischemic stroke subtypes. When adjusting models by multiple factor analysis by logistic regression, then calculated 10,000 permutations were performed for each model to correct the multiple test. Under additive model, the rs243327 was associated with ischemic stroke with hypertension (p = 0.047). Under heterozygous model, the rs33932899 and rs243330 were significantly associated with ischemic stroke subtypes by atherosclerosis (p = 0.038, p = 0.048, respectively). In summary, our data demonstrated for the first time that the polymorphisms of the SOCS1 gene are associated with the risk of ischemic stroke in a northern Chinese Han population, suggesting that SOCS1 gene polymorphisms may play an important role in the pathogenesis of ischemic stroke.
缺血性脑卒中是一种常见的神经系统疾病，也是许多国家导致永久性残疾的主要原因。最近的研究提供了证据，表明细胞因子信号转导抑制因子 1（SOCS1）基因在动脉粥样硬化病变的发生和发展中起作用。然而，很少有研究评估 SOCS1 基因上的单核苷酸多态性（SNP）与缺血性脑卒中之间的关系。因此，本研究旨在探讨 SOCS1 多态性在中国北方汉族人群中与缺血性脑卒中风险的关系。我们检查了 475 例缺血性脑卒中患者和 486 例正常对照。使用 TaqMan 基因分型检测 SOCS1 基因的 3 个 SNP（rs243327、rs243330 和 rs33932899）。我们还通过并发症高血压或糖尿病和缺血性脑卒中亚型对这些病例样本进行了深入分类。通过多元逻辑回归的多元因素分析调整模型后，对每个模型进行了 10000 次随机排列以校正多重检验。在加性模型中，rs243327 与伴高血压的缺血性脑卒中相关（p=0.047）。在杂合模型中，rs33932899 和 rs243330 与动脉粥样硬化性缺血性脑卒中亚型显著相关（p=0.038，p=0.048）。总之，我们的数据首次表明，SOCS1 基因的多态性与中国北方汉族人群缺血性脑卒中的风险相关，表明 SOCS1 基因多态性可能在缺血性脑卒中的发病机制中起重要作用。
