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Researches on antiinflammatory agents. Studies on some 1-methyl- or 1-phenyl-6-(2-substitutedphenyl)-pyrazolo[3,4-d]-1,3-oxazin-4(1H)-ones.

作者信息

Daidone G, Bajardi M L, Roccaro A, Raffa D, Caruso A, Cutuli V, Di Pietro E

机构信息

Dipartimento di Chimica e Tecnologie Farmaceutiche, Università di Palermo.

出版信息

Farmaco. 1991 Jul-Aug;46(7-8):945-57.

PMID:1793477
Abstract

Following our research on analgesic and antiinflammatory active compounds containing the pyrazole nucleus, a number of new 1-methyl- or 1-phenyl-6-(2-substitutedphenyl)-pyrazolo[3,4-d]-1,3-oxazin- 4(1H)-ones was synthesized and tested, together with a few analogues previously obtained, for their analgesic and antiinflammatory activities, as well as for their acute toxicity and ulcerogenic effects. One of the tested compounds showed activity comparable to that of phenylbutazone and, at the same time, higher LD50 and a very low ulceration index.

摘要

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