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[菊池-藤本病:5例报告及文献复习]

[Kikuchi-Fujimoto's disease: report of 5 cases and literature review].

作者信息

Adjaoud D, Boudjemaa S, Boccon-Gibod L, Leverger G

机构信息

Service d'hématologie et d'oncologie pédiatriques, hôpital d'enfants Armand-Trousseau, Assistance publique-Hôpitaux de Paris, 26, avenue du Docteur-A.-Netter, 75012 Paris, France.

出版信息

Arch Pediatr. 2007 Nov;14(11):1333-6. doi: 10.1016/j.arcped.2007.07.015. Epub 2007 Oct 23.

Abstract

Kikuchi-Fujimoto's disease or histiocytic necrotizing lymphadenitis is a benign disease predominantly occurring in young women which etiology remains unknown and revealed by cervical lymphadenitis and/or prolonged fever. It has rarely been reported in children. Among the 5 cases reported, 1 child had a systemic localization. The diagnosis is based on the histological examination of a lymph node biopsy. The disease course was spontaneously favourable in 2 cases; a corticotherapy was needed in 3 children. A pathogen agent was found in 2 patients. Kikuchi's disease can reveal or evolve into autoimmune disease particularly lupus, thus a long clinical and biological follow-up is necessary.

摘要

菊池-藤本病或组织细胞坏死性淋巴结炎是一种主要发生于年轻女性的良性疾病,其病因不明,以颈部淋巴结炎和/或长期发热为表现。儿童中鲜有报道。在已报道的5例病例中,1例患儿有全身病变。诊断基于淋巴结活检的组织学检查。2例患者病程呈自发好转;3例患儿需要进行皮质激素治疗。2例患者发现了病原体。菊池病可引发或演变为自身免疫性疾病,尤其是狼疮,因此需要进行长期的临床和生物学随访。

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