Mootsikapun Piroon, Sirijerachai Jittima, Nanagara Ratanavadee
Department of Internal Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
J Med Assoc Thai. 2002 Sep;85(9):1037-41.
Kikuchi-Fujimoto's disease (KFD) or histiocytic necrotizing lymphadenitis is a self-limiting condition characterized by fever, neutropenia and lymphadenopathy. It is rarely associated with systemic lupus erythematosus (SLE). The authors reported a case of Kikuchi's necrotizing lymphadenitis who presented with fever, generalized lymphadenopathy, moderate leukopenia, polyarthritis, vasculitis-like lesions and oral ulcers compatible with SLE but serologic tests for autoimmune disease were all negative. The clinical symptoms resolved spontaneously within 3 months without any treatment. Because there is an association between KFD and SLE, great care should be taken with a patient who presents with either KFD or SLE.
菊池-藤本病（KFD）或组织细胞坏死性淋巴结炎是一种自限性疾病，其特征为发热、中性粒细胞减少和淋巴结病。它很少与系统性红斑狼疮（SLE）相关。作者报告了一例菊池坏死性淋巴结炎患者，该患者表现出发热、全身淋巴结病、中度白细胞减少、多关节炎、血管炎样病变和口腔溃疡，这些表现与SLE相符，但自身免疫性疾病的血清学检查均为阴性。临床症状在未接受任何治疗的情况下于3个月内自行缓解。由于KFD与SLE之间存在关联，对于出现KFD或SLE的患者应格外小心。
