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后尿道狭窄患者下尿路功能的保留:尿道支架置入术合适患者的选择

Preservation of lower urinary tract function in posterior urethral stenosis: selection of appropriate patients for urethral stents.

作者信息

Eisenberg Michael L, Elliott Sean P, McAninch Jack W

机构信息

University of California-San Francisco and San Francisco General Hospital, San Francisco, California 94110, USA.

出版信息

J Urol. 2007 Dec;178(6):2456-60; discussion 2460-1. doi: 10.1016/j.juro.2007.08.013. Epub 2007 Oct 15.

Abstract

PURPOSE

We describe our experience with urethral stents to manage iatrogenic posterior urethral stenosis.

MATERIALS AND METHODS

We surveyed our retrospective database for patients in whom we placed a urethral stent for posterior urethral stricture disease. We reviewed patient age, comorbidities, indications for stent placement, stricture length, postoperative complications and the repeat stenosis rate.

RESULTS

Overall we placed urethral stents in 13 patients, of whom 12 presented with posterior urethral stenosis and 1 presented with anterior and posterior stricture. The etiology of urethral stricture was prostate cancer therapy in 11 of 13 cases and simple prostatectomy in 2. Urethral stenting was chosen instead of urethral reconstruction largely due to prior radiation for prostate cancer and avoidance of the morbidity of surgery. Overall 6 of 13 patients required additional procedures for stricture recurrence, including 5 in previously irradiated patients. Two patients had stents removed due to migration or pain. Genitourinary infections developed in 5 of 13 patients. Eight of 13 patients with a posterior urethral stricture were incontinent, as expected after stent placement. Incontinence was managed by an artificial urinary sphincter in willing patients with 9 of 13 continent.

CONCLUSIONS

Urethral stents provide reasonable treatment for patients with posterior urethral stenosis when attempting to preserve lower urinary tract function caused by stricture disease after prostate cancer therapy. Prior radiation seems to increase the failure rate. Continence can be maintained after posterior urethral stenting in select patients.

摘要

目的

我们描述使用尿道支架治疗医源性后尿道狭窄的经验。

材料与方法

我们在回顾性数据库中调查了因后尿道狭窄疾病而置入尿道支架的患者。我们回顾了患者的年龄、合并症、支架置入指征、狭窄长度、术后并发症及再狭窄率。

结果

总体而言,我们为13例患者置入了尿道支架,其中12例为后尿道狭窄,1例为前后尿道均狭窄。13例患者中,11例尿道狭窄的病因是前列腺癌治疗,2例是单纯前列腺切除术。选择尿道支架置入而非尿道重建主要是由于既往有前列腺癌放疗史以及避免手术带来的并发症。13例患者中总体有6例因狭窄复发需要额外治疗,其中5例为既往接受过放疗的患者。2例患者因支架移位或疼痛而取出支架。13例患者中有5例发生泌尿生殖系统感染。13例后尿道狭窄患者中有8例出现尿失禁,这在支架置入后是预期的情况。对于有意愿的患者,通过人工尿道括约肌来处理尿失禁问题,13例患者中有9例控尿。

结论

当试图保留前列腺癌治疗后狭窄疾病所致的下尿路功能时,尿道支架可为后尿道狭窄患者提供合理的治疗。既往放疗似乎会增加失败率。部分患者在后尿道支架置入后可维持控尿。

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