Turk Dennis C, Dworkin Robert H, Revicki Dennis, Harding Gale, Burke Laurie B, Cella David, Cleeland Charles S, Cowan Penney, Farrar John T, Hertz Sharon, Max Mitchell B, Rappaport Bob A
University of Washington, Seattle, WA, USA University of Rochester, Rochester, NY, USA United BioSource Corporation, Bethesda, MD, USA United States Food and Drug Administration, Rockville, MD, USA Northwestern University, Chicago, IL, USA MD Anderson Cancer Center, Houston, TX, USA American Chronic Pain Association, Rocklin, CA, USA University of Pennsylvania, Philadelphia, PA, USA National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
Pain. 2008 Jul 15;137(2):276-285. doi: 10.1016/j.pain.2007.09.002. Epub 2007 Oct 15.
This two-phase study was conducted to identify relevant domains of patient-reported outcomes from the perspective of people who experience chronic pain. In Phase 1, focus groups were conducted to generate a pool of patient outcome-related domains and their components. The results of the focus groups identified 19 aspects of their lives that were significantly impacted by the presence of their symptoms and for which improvements were important criteria they would use in evaluating the effectiveness of any treatment. Phase 2 was conducted to examine the importance and relevance of domains identified from a much larger and diverse sample of people with chronic pain. A survey was developed and posted on the American Chronic Pain Association website. Participants were asked to rate the importance of each item or domain identified by the focus groups on a scale of 0 to10 (i.e., 0="not at all important" and 10="extremely important"). The survey was completed by 959 individuals. The results indicate that all 19 aspects of daily life derived from the focus groups were considered important with a majority of respondents indicating a score of 8 or greater. In addition to pain reduction, the most important aspects were enjoyment of life, emotional well-being, fatigue, weakness, and sleep-related problems. Chronic pain clearly impacts health-related quality of life. The results of the two phases of the study indicate that people with chronic pain consider functioning and well-being as important areas affected by the presence of symptoms and as appropriate targets of treatment. These multiple outcomes should be considered when evaluating the efficacy and effectiveness of chronic pain treatments.
这项两阶段研究旨在从慢性疼痛患者的角度确定患者报告结局的相关领域。在第一阶段，开展了焦点小组讨论以生成一系列与患者结局相关的领域及其组成部分。焦点小组讨论的结果确定了他们生活中的19个方面，这些方面受到症状的显著影响，并且改善是他们评估任何治疗效果时所使用的重要标准。第二阶段旨在检验从更大且更多样化的慢性疼痛患者样本中确定的领域的重要性和相关性。开发了一项调查并发布在美国慢性疼痛协会网站上。参与者被要求按照0到10的评分标准对焦点小组确定的每个项目或领域的重要性进行评分（即，0 =“完全不重要”，10 =“极其重要”）。959人完成了这项调查。结果表明，焦点小组得出的所有19个日常生活方面都被认为很重要，大多数受访者给出的评分在8分或更高。除了疼痛减轻外，最重要的方面是生活乐趣、情绪健康、疲劳、虚弱和睡眠相关问题。慢性疼痛显然会影响与健康相关的生活质量。该研究两个阶段的结果表明，慢性疼痛患者认为功能和健康是受症状影响的重要领域，也是合适的治疗目标。在评估慢性疼痛治疗的疗效和效果时，应考虑这些多重结局。
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