Griffin John R, Cohen Philip R, Tschen Jaime A, Mullans Elizabeth A, Schulze Keith E, Martinelli Paul T, Nelson Bruce R
Medical School, University of Texas-Houston Medical School, USA.
J Am Acad Dermatol. 2007 Nov;57(5 Suppl):S97-102. doi: 10.1016/j.jaad.2006.09.032.
Childhood onset basal cell carcinoma is uncommon. In addition to occurring in children with albinism, Bazex syndrome, basal cell carcinoma nevus syndrome, nevus sebaceus, radiotherapy-treated cancers, solid organ transplants, and xeroderma pigmentosum, childhood onset basal cell carcinoma has also occurred, albeit less commonly, de novo. We describe a boy with idiopathic childhood onset basal cell carcinoma. Previously published children with de novo basal cell carcinoma were collected from computerized medical literature search (PubMed) and citations from earlier reports. To our knowledge, childhood onset idiopathic basal cell carcinoma has been observed in a total of 107 children, including our patient. Tumors were most commonly located on the head (90%). The tumors are most frequently nodular in appearance (52%) and in histology (at least 17%); however, aggressive histologic variants were observed in 20% of tumors. Basal cell carcinoma in children may be associated with prior sun exposure. The most common treatment is excision, with or without using the Mohs technique. However, 15 of 85 children, nearly 20%, developed recurrent tumors during a follow-up period ranging from 4 months to 20 years.
儿童期起病的基底细胞癌并不常见。除了发生于患有白化病、巴泽克斯综合征、基底细胞癌痣综合征、皮脂腺痣、接受过放射治疗的癌症患者、实体器官移植受者以及着色性干皮病的儿童外，儿童期起病的基底细胞癌也有散发病例，尽管较为少见。我们描述了一名患有特发性儿童期起病基底细胞癌的男孩。通过计算机化医学文献检索（PubMed）以及早期报告的参考文献收集了此前发表的散发性基底细胞癌患儿病例。据我们所知，包括我们的患者在内，总共观察到107例儿童期起病的特发性基底细胞癌。肿瘤最常见于头部（90%）。肿瘤外观上最常见为结节状（52%），组织学上也是如此（至少17%）；然而，20%的肿瘤观察到侵袭性组织学变体。儿童基底细胞癌可能与既往日晒有关。最常见的治疗方法是切除，可使用或不使用莫氏手术技术。然而，85名儿童中有15名，近20%，在4个月至20年的随访期内出现了复发性肿瘤。
