孕产妇艾滋病毒感染与子宫内生长：尼日利亚拉各斯的一项前瞻性研究。

Maternal HIV infection and intrauterine growth: a prospective study in Lagos, Nigeria.

作者信息

Iroha E O, Ezeaka V C, Akinsulie A O, Temiye E O, Adetifa I M O

机构信息

Department of Pediatrics, College of Medicine of the University of Lagos, Lagos, Nigeria.

出版信息

West Afr J Med. 2007 Apr-Jun;26(2):121-5.

PMID:17939313

Abstract

BACKGROUND

Low birth weight (LBW) is the most important cause of perinatal mortality and morbidity worldwide and particularly so in developing countries. Maternal HIV (Human Immunodeficiency Virus) infection has been identified as one of the risk factors to the development of low birth weight babies.

OBJECTIVE

To evaluate the effect of maternal HIV infection on the birth weight of the newborn at tertiary hospital in West Africa.

METHODS

The anthropometry of all HIV seropositive women who delivered in LUTH as well as that of their babies was determined using standard methods. Controls consisted of HIV seronegative women and their babies matched for age and parity with the above subjects.

RESULTS

There were a total of 262 subjects of whom 132 (50.4%) were HIV seropositive and 130 (49.6%) were HIV seronegative controls. There were five times more low birth weight (LBW) infants in the HIV seropositive group than in the controls (OR 5.77, CI=2.19-16.80; p=0.000075). The mean maternal body mass index, BMI (p=0.0003), mean maternal weight (p=0.0004) and mean birth weight of newborns (p=0.0002) were significantly lower in the HIV seropositive group than in the controls. Maternal weight and gestational age were significantly associated with low birth weight (OR 15.3, CI=2.6-316.0; p=0.002) and (OR 3.78, CI=1.37-10.9; p=0.007) respectively.

CONCLUSION

Maternal HIV infection is strongly associated with low maternal BMI and low birth weight in their offspring.

摘要

背景

低出生体重是全球围产期死亡率和发病率的最重要原因，在发展中国家尤其如此。孕产妇感染艾滋病毒（人类免疫缺陷病毒）已被确定为低出生体重儿发生的危险因素之一。

目的

评估西非一家三级医院中孕产妇感染艾滋病毒对新生儿出生体重的影响。

方法

采用标准方法测定在拉各斯大学教学医院分娩的所有艾滋病毒血清阳性妇女及其婴儿的人体测量数据。对照组由年龄和胎次与上述受试者匹配的艾滋病毒血清阴性妇女及其婴儿组成。

结果

共有262名受试者，其中132名（50.4%）为艾滋病毒血清阳性，130名（49.6%）为艾滋病毒血清阴性对照组。艾滋病毒血清阳性组的低出生体重儿数量是对照组的五倍（比值比5.77，可信区间=2.19-16.80；p=0.000075）。艾滋病毒血清阳性组的孕产妇平均体重指数（p=0.0003）、孕产妇平均体重（p=0.0004）和新生儿平均出生体重（p=0.0002）均显著低于对照组。孕产妇体重和孕周分别与低出生体重显著相关（比值比15.3，可信区间=2.6-316.0；p=0.002）和（比值比3.78，可信区间=1.37-10.9；p=0.007）。