Sharma Arun K, Gowdahalli Krishnegowda, Krzeminski Jacek, Amin Shantu
Department of Pharmacology, Chemical Carcinogenesis and Chemoprevention Program of Penn State Cancer Institute, Penn State College of Medicine, Hershey, PA 17033, USA.
J Org Chem. 2007 Nov 9;72(23):8987-9. doi: 10.1021/jo701665j. Epub 2007 Oct 16.
A highly efficient and general method for Suzuki cross-coupling reaction en route to the synthesis of polycyclic aromatic hydrocarbons (PAHs) and their metabolites has been developed. Microwave irradiation of aryl bromides 1 and boronic acids (2 and 3) using polyurea microencapsulated palladium catalyst (Pd EnCat 30) gave the coupling adducts 4 and 5 in excellent yields in just 20 min compared to approximately 24 h under thermal conditions, corresponding to a approximately 72-fold increase in reaction rate.
已开发出一种高效通用的方法，用于在多环芳烃（PAHs）及其代谢物合成过程中的铃木交叉偶联反应。使用聚脲微囊化钯催化剂（Pd EnCat 30）对芳基溴化物1与硼酸（2和3）进行微波辐射，在仅20分钟内就以优异的产率得到偶联加合物4和5，而在热条件下大约需要24小时，这相当于反应速率提高了约72倍。
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