微波辅助有机合成核苷前药类似物。
Microwave-assisted organic synthesis of nucleoside ProTide analogues.
作者信息
Bordoni Cinzia, Cima Cecilia Maria, Azzali Elisa, Costantino Gabriele, Brancale Andrea
机构信息
School of Pharmacy and Pharmaceutical Sciences Redwood Building, King Edward VII Avenue CF10 3NB Cardiff UK
P4T Group, Dipartimento di Farmacia, University of Parma Parco Area delle Scienze 27/A Parma 43124 Italy.
出版信息
RSC Adv. 2019 Jun 27;9(35):20113-20117. doi: 10.1039/c9ra01754b. eCollection 2019 Jun 25.
A microwave enhanced synthesis of prodrug nucleotide (ProTide) analogues is presented. Comparison of conventional thermal heating reaction with microwave irradiation exemplifies the potential of the novel methodology herein presented for the selective 5'-phosphoramidate synthesis, without protection of the 3' position in the ribonucleoside.
本文介绍了一种微波增强的前药核苷酸（ProTide）类似物的合成方法。将传统热加热反应与微波辐射进行比较，例证了本文所提出的新方法在选择性5'-氨基磷酸酯合成方面的潜力，且无需对核糖核苷的3'位进行保护。
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