胺诱导的迈克尔/共轭烯加成级联反应：在（±）-Clavukerin A 的形式合成中的应用。
Amine-induced Michael/Conia-ene cascade reaction: application to a formal synthesis of (+/-)-Clavukerin A.
机构信息
Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen University Town, Xili, Shenzhen 518055, China.
出版信息
Org Lett. 2010 Feb 5;12(3):548-51. doi: 10.1021/ol902567e.
PMID:20028120
Abstract
An efficient and versatile amine-induced Michael/Conia-ene cascade cyclization reaction has been developed for establishing 6,6- and 5,7-bicyclic fused carbocycles with simple acyclic beta-ketoesters as the substrates in one-pot condition and this new cyclization method has been successfully utilized in a formal synthesis of (+/-)-Clavukerin A.
摘要
发展了一种高效、通用的胺诱导的迈克尔/共轭烯加成环化反应，用于在一锅条件下建立具有简单非环β-酮酯作为底物的 6,6-和 5,7-双环稠合碳环，这种新的环化方法已成功应用于 (+/-)-Clavukerin A 的形式合成。
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