树突棘激发单脉冲长时程增强效应。
Dendritic spikes induce single-burst long-term potentiation.
作者信息
Remy Stefan, Spruston Nelson
机构信息
Department of Neurobiology and Physiology, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, USA.
出版信息
Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17192-7. doi: 10.1073/pnas.0707919104. Epub 2007 Oct 16.
Abstract
The hippocampus is essential for episodic memory, which requires single-trial learning. Although long-term potentiation (LTP) of synaptic strength is a candidate mechanism for learning, it is typically induced by using repeated synaptic activation to produce precisely timed, high-frequency, or rhythmic firing. Here we show that hippocampal synapses potentiate robustly in response to strong activation by a single burst. The induction mechanism of this single-burst LTP requires activation of NMDA receptors, L-type voltage-gated calcium channels, and dendritic spikes. Thus, dendritic spikes are a critical trigger for a form of LTP that is consistent with the function of the hippocampus in episodic memory.
摘要
海马体对于情景记忆至关重要，情景记忆需要单次试验学习。虽然突触强度的长时程增强（LTP）是一种学习的候选机制，但它通常是通过重复突触激活来诱导产生精确计时、高频或节律性放电。在这里我们表明，海马体突触在单次爆发的强烈激活下会有力地增强。这种单次爆发LTP的诱导机制需要NMDA受体、L型电压门控钙通道和树突棘的激活。因此，树突棘是一种与海马体在情景记忆中的功能相一致的LTP形式的关键触发因素。
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