Rasmussen Morten S
Department of Surgery, Bispebjerg Hospital, Copenhagen, Denmark.
Curr Opin Pulm Med. 2007 Sep;13(5):389-92. doi: 10.1097/MCP.0b013e3282058ba6.
To analyze the effect of prolonged thromboprophylaxis with low molecular weight heparin in patients undergoing major abdominal surgery.
Literature searches in PubMed, EMBASE and Cochrane Database between 1990 and 2006 were conducted to identify trials concerning prolonged thromboprophylaxis in major abdominal surgery. Three randomized controlled trials met the search criteria. They showed that low molecular weight heparin is effective and safe to use as prolonged thromboprophylaxis after major abdominal surgery.
Three published randomized studies all show a 50-60% relative risk reduction of late occurring deep venous thrombosis after major abdominal surgery. Evidence for the use of prolonged thromboprophylaxis after major abdominal surgery is emerging, and seems justified in selected high-risk patients, including patients operated on for cancer.
分析低分子量肝素延长预防血栓形成对接受腹部大手术患者的影响。
检索了1990年至2006年间的PubMed、EMBASE和Cochrane数据库，以确定有关腹部大手术延长预防血栓形成的试验。三项随机对照试验符合检索标准。这些试验表明，低分子量肝素用于腹部大手术后延长预防血栓形成是有效且安全的。
三项已发表的随机研究均显示，腹部大手术后晚期发生深静脉血栓形成的相对风险降低了50%至60%。腹部大手术后延长预防血栓形成的证据正在出现，在选定的高危患者中似乎是合理的，包括接受癌症手术的患者。
