Agnelli Giancarlo, Caprini Joseph A
Stroke Unit and Cardiovascular Medicine, University of Perugia, Perugia, Italy.
J Surg Oncol. 2007 Sep 1;96(3):265-72. doi: 10.1002/jso.20808.
Cancer is a risk factor for venous thromboembolism (VTE). This risk is amplified by treatment with chemotherapy, radiation, or surgery. Thus, patients with cancer undergoing major surgery should receive appropriate prophylaxis. Available agents include low-dose unfractionated heparin (LDUH), low-molecular-weight heparin (LMWH), and Factor Xa inhibitors. Recent data suggest that Factor Xa inhibitors are safe and effective for VTE prevention in patients with cancer undergoing abdominal surgery. Further study in this patient population is warranted.
癌症是静脉血栓栓塞（VTE）的一个风险因素。化疗、放疗或手术治疗会加剧这种风险。因此，接受大手术的癌症患者应接受适当的预防措施。可用的药物包括低剂量普通肝素（LDUH）、低分子肝素（LMWH）和Xa因子抑制剂。最近的数据表明，Xa因子抑制剂对于接受腹部手术的癌症患者预防VTE是安全有效的。有必要对这一患者群体进行进一步研究。
