Sonpavde Guru, Chi Kim N, Powles Thomas, Sweeney Christopher J, Hahn Noah, Hutson Thomas E, Galsky Matthew D, Berry William R, Kadmon Dov
Genitourinary Oncology Program, U.S. Oncology Research, Houston, Texas, USA.
Cancer. 2007 Dec 15;110(12):2628-39. doi: 10.1002/cncr.23085.
The results of this assessment of the literature indicated that neoadjuvant therapy followed by prostatectomy may improve long-term outcomes for patients with high-risk localized disease. In addition, this approach provides a paradigm for evaluating the activity and mechanism of action of new agents as correlative studies are facilitated by the availability of tumor tissue before and after therapy. The authors determined that a multidisciplinary approach involving oncologists, urologists, and pathologists is critical to the success of this model. Recent and ongoing studies of neoadjuvant therapy followed by prostatectomy were reviewed.
对文献的评估结果表明,新辅助治疗后行前列腺切除术可能会改善高危局限性疾病患者的长期预后。此外,由于治疗前后均可获得肿瘤组织,便于进行相关性研究,这种方法为评估新药物的活性和作用机制提供了一个范例。作者认为,肿瘤学家、泌尿科医生和病理学家参与的多学科方法对该模式的成功至关重要。本文回顾了近期及正在进行的新辅助治疗后行前列腺切除术的研究。