用于功能分析的活化微孔中的细胞捕获
Cell trapping in activated micropores for functional analysis.
作者信息
Talasaz AmirAli H, Powell Ashley A, Stahl Patrik, Ronaghi Mostafa, Jeffrey Stefanie S, Mindrinos Michael, Davis Ronald W
机构信息
Electr. Eng. Dept., Stanford Univ., CA 94305, USA.
出版信息
Conf Proc IEEE Eng Med Biol Soc. 2006;2006:1838-41. doi: 10.1109/IEMBS.2006.260233.
This paper presents a novel device which provides the opportunity to perform high-throughput biochemical assays on different individual cells. In particular, the proposed device is suited to screen the rare cells in biological samples for early stage cancer diagnosis and explore their biochemical functionality. In the process, single cells are precisely positioned and captured in activated micropores. To show the performance of the proposed device, cultured yeast cells and human epithelial circulating tumor cells are successfully captured.
本文介绍了一种新型设备，该设备为在不同单个细胞上进行高通量生化分析提供了机会。特别是，所提出的设备适用于筛选生物样品中的稀有细胞以进行早期癌症诊断，并探索它们的生化功能。在此过程中，单个细胞被精确地定位并捕获在活化的微孔中。为了展示所提出设备的性能，成功捕获了培养的酵母细胞和人上皮循环肿瘤细胞。
Zotero 插件